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2016年10月,恶性血液病研究部何苏丹博士课题组与功能纳米与软物质研究院何耀博士课题组合作在Biomaterials杂志上发表论文

发布日期:2017/03/23

    2016年10月,何苏丹博士课题组与功能纳米与软物质研究院何耀博士课题组合作在Biomaterials杂志上发表题为“Aqueous synthesized quantum dots interfere with the NF-kB pathway and confer anti-tumor, anti-viral and anti-inflammatory effects”的论文,此研究发现了高效抑制NF-kB途径的纳米材料碲化镉量子点,并揭示了其促进肿瘤细胞死亡以及在体内抑制炎症反应的生物学功能,为纳米材料的生物学应用提供新的科学依据。

 Biomaterials. 2016 Nov;108:187-96. doi: 10.1016/j.biomaterials.2016.08.047. Epub 2016 Aug 31.

 题目:

Aqueous synthesized quantum dots interfere with the NF-κB pathway and confer anti-tumor, anti-viral and anti-inflammatory effects.

作者:

Hu Z1, Song B2, Xu L1, Zhong Y2, Peng F2, Ji X2, Zhu F1, Yang C1, Zhou J1, Su Y2, Chen S3, He Y4, He S5.

单位:

1Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou 215123, China.

2Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China.

3Jiangsu Institute of Hematology (JIH), Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.

4Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China. Electronic address: yaohe@suda.edu.cn.

5Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou 215123, China. Electronic address: hesudan@suda.edu.cn.

摘要:

The NF-κB pathway plays crucial roles in inflammatory responses and cell survival. Aberrant constitutive NF-κB activation is associated with various human diseases including cancer and inflammatory and auto-immune diseases. Consequently, it is highly desirable to develop new kinds of inhibitors, which are highly efficacious for blocking the NF-κB pathway. In this study, by using a typical kind of aqueous synthesized quantum dots (QDs), i.e., CdTe QDs, as a model, we for the first time demonstrated that the QDs could selectively affect the cellular nuclear factor-κB (NF-κB) signaling pathway, but do not affect the AKT or ERK pathways. Typically, the QDs efficiently inhibited the activation of IKKα and IKKβ, resulting in the suppression of both the canonical and the non-canonical NF-κB signaling pathways. Inhibition of NF-κB by QDs downregulates anti-apoptotic genes and promotes apoptosis in cancer cells. The QDs induced NF-κB inhibition and cytotoxicity could be blocked by N-acetylcysteine due to the reduced cellular uptake of QDs. Importantly, inhibition of NF-κB by QDs displayed promising effects against the viral replication and in vivo bacterial endotoxin-induced inflammatory responses. These data suggest the QDs as potent inhibitors of the NF-κB signaling pathway, both in vitro and in vivo. Our findings highlight the potential of using QDs in the development of anti-cancer, anti-viral, and anti-inflammatory approaches, and also facilitate better understanding of QDs-related cellular behavior under the molecular level.

 

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